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Divergent functions of the duplicated genes might help permanent preservation of the genes.
Based on the structures of wt-KaiC and six mutants and in conjunction with data from site-specific mutations (Fig. 3), the divergent functions of the CI and CII halves in the control of the KaiABC oscillator and the roles of individual residues underlying the mechanisms of the kinase (CII half) and ATPase (CI and CII halves) activities can be revisited.
Undoubtedly these differences will contribute to the divergent functions of the different homologous DD.
At present, it is unclear whether the various Psg genes exhibit different cellular expression patterns, which might indicate divergent functions of the various PSGs.
Thus, our mouse model gives new insights into the divergent functions of the V-ATPase and the pathophysiology of a4-related symptoms.
The HP1 family of proteins were identified more than 20 years ago (James & Elgin, 1986), but the common or divergent functions of the three isoforms remain largely unknown.
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Numerous studies to understand the specificity difference of σ70 and σ38 have revealed only some clues to explain the divergent functions of these rather homologous sigma factors [51], [52], [53], [54], [55], [56], [57].
Unraveling the divergent functions of these receptors and their relative roles in subpopulations of patients with RA is just the dawn of TLR-targeted therapy.
These N-terminal extensions suggest probable misannotation or divergent functions of these two genes which require further experimental evidence.
However, significant adult developmental defects, including fused proximal leg segments and poorly developed abdomen, suggest common but potentially divergent functions of these paralogous genes (Bessa et al., 2009).
The differences in post-translational modifications might play important roles in divergent function of the new isoform.
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