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These cytokines have divergent functions, and determine the nature of the response.
There are likely important behavioral differences between these populations, but the ten genes contained within this GO term, appear to be genes that have many divergent functions and the behavioural annotations are mostly related to mice.
A major challenge of conifer transcriptome analysis is the proper assembly of FL sequences of members of multigene families, where closely related members have divergent functions, and which are characteristic of secondary metabolism.
However, the downstream AKT pathway is mainly required to sustain proliferation and survival (inhibiting AKT following NGF-TrkA stimulus accentuates cell lost and growth arrest), while the MAPK pathway may also have divergent functions and mediate an anti-proliferative signaling in response to NFG-TrkA activation (cell viability is improved when MAPK is inhibited following the NGF-TrkA stimulus).
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As random shuffled gene pairs should have divergent function and expression patterns, we utilized r < 0.59 as an indicator of divergent expression.
Also consistent with our observations, Richter et al. reported that independent of its role in generating Nox2-dependent ROS, p47phox is an important protein for integrating signaling downstream of TLR9 in mouse dendritic cells, thus supporting the idea of distinct and divergent functions for gp91phox and p47phox.
Pituitary adenylate cyclase activating polypeptide (PACAP) expressed in capsaicin-sensitive sensory neurons and immune cells has divergent functions in inflammatory and pain processes.
The preliminary data suggested that dmrt2b and dmrt2a might have both common functions and divergent functions.
Another possible mechanism leading to the divergent functions of Lrp5 and 6 may be cell surface presentation and intracellular processing of the receptors.
This new model proposes that a large part of duplicated genes might play both overlapping functions and divergent functions [44].
Gaining an understanding as to how these apparently divergent functions are interrelated and controlled could elucidate new therapeutic strategies designed to harness the neuroprotective activity of IFNγ.
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