ATR-deficient plants do not show somatic or meiotic defects, a divergent characteristic compared to humans.
Hence, divergent mechanisms underlie hematopoietic defects in DBA patients with different RP mutations.
While untreated protonemata grow vertically, GA3 treated ones grew in various direction showing angles divergent from the vertical, suggesting a defect in gravitropism.
(PR 80 toxicity was not suppressed by Notch expression, and PR80 expression in N 5419 /+ background did not significantly enhance the PR80 wing defect (not shown), suggesting divergent pathogenic mechanisms of these two DPRs.
Nevertheless, previous attempts to show a specific genetic defect in FM yielded weak and/or divergent results.
However, it is not clear how mutations in the same gene can have divergent consequences, ranging from severe ID to prominent social defects with preserved intellectual function.
10, 18 Restoration of the IPMK products, IP4 and IP5, by overexpressing the IPMK gene from evolutionarily divergent plant or fruit fly functionally rescues the growth defect in IPMK-null yeast cells.
Genetic crosses in the laboratory involving model organisms have identified loci and genes causing hybrid defects, a common type of reproductive barrier caused by genetic interactions between divergent alleles at two or more loci (Bateson, 1909; Dobzhansky, 1937; Muller, 1942).
However, significant adult developmental defects, including fused proximal leg segments and poorly developed abdomen, suggest common but potentially divergent functions of these paralogous genes (Bessa et al., 2009).
We found that sorbitol could not rescue the growth defects of C. gattii or C. neoformans calcineurin mutants at 37° (data not shown), suggesting divergent roles of calcineurin for controlling osmotic responses between Cryptococcus species and C. glabrata.
