As powerful drivers of diapedesis, the chemokines CCL2 and CCL5 have long been implicated in hypertension, but experimental data highlight divergent, context-specific effects of these chemokines on blood pressure and tissue injury.
The divergent molecular context of cellular networks that mediate glucocorticoid adverse effects (for example, corticotrophs or hepatocytes) do not support amplification, and therefore the safety profile of the very-low-dose glucocorticoid is maintained.
The extent to which these dynamics will drive evolutionary change will depend in part on individual mobility and gene flow between divergent nutritional contexts.
These divergent research contexts were evident in the differential make-up of participants to the three in-country workshops held as part of the project.
For example, the A AAA AAG motif found in dnaX and in many insertion sequences of the IS3 family has been considered the most efficient heptameric -1 shift motif in E. coli [ 10]. C. albicans and D. hansenii non-standard serine-CTG and standard leucine-CTG codons of the other fungal ORFeomes had divergent triplet-context preferences.
This article examines divergent adaptations in the context of land tenure shifts in the pastoral zone of Niger.
This study shows for the first time the interest of combining selective sweeps mapping, coding SNP annotation and cis-eQTL analyses for identifying causative genes for a complex trait, in the context of divergent lines selected for this specific trait.
To objectively evaluate the comparative strength of these divergent perspectives in the context of salmonid captive breeding programs, the evidence for each one must firstly be carefully sifted and presented (see Appendix 1 for details of the literature search).
These observations indicate that selection operating on males and females may often be divergent and that the context within which a mutation exerts its phenotypic effect(s) is likely to differ between the sexes.
In mammalian cells, the kinase exists as a heterotrimer comprised of a single α (catalytic) subunit in addition to two ß and γ regulatory subunits— as such, variant AMPK complexes exist and may be divergent dependent on cellular context.
We also performed the same analysis on two splice variants of Fyn (Fyn1 and Fyn2), which contain divergent linkers within the context of nearly identical SH3, SH2, and CDs.
