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Fusion-negative and fusion-positive RMS are distinct tumor subtypes, with different pathways of oncogenic deregulation, and likely divergent cells of origin (reviewed in ref. 1).
Although clearly neurons and pollen tubes are evolutionarily divergent cells, they are both highly polarized with large energy needs.
It is possible that a stem cell gene regulatory network and the stem cells themselves share more conserved molecular similarities than differentiated divergent cells.
Since PBMC contain divergent cells, the use of unseparated PBMC could complicate the interpretation of the results, as pointed out by Hou et al [ 1].
For example, only ∼25% of divergent cells showed pGAL1 activation at 0.2% galactose, whereas ∼75% of serial and convergent cells showed pGAL1 activation at the same galactose concentration.
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Han, D. et al. IRE1a kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
The intricate machinery required to establish and maintain divergent cell fates within a syncytium, and the importance of associated oocyte patterning for subsequent embryonic development, have made polarized cysts valuable subjects of study in developmental and cell biology.
Meanwhile, the presence of ParC may induce a different microenvironment that leads to divergent cell metabolism and cell-cell interactions.
Breast cancer is a multi-faced disease where histologically divergent cell populations interact to carry out aberrant programs of development.
Not surprisingly, CMCs and PBMCs have divergent cell population make-ups, which critical to our understanding of immune responses at the FGT.
While such "precancers" may still lack key mutations for complete oncogenic transformation, such observations also suggest that important aspects of a genetically divergent cell's environment may be critical in its eventual development into a physiologically significant tumor.
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