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Given the difference in seed localization, we predicted targets for the divergent cases of the Gly and mt:SerGCT tRFs.
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In our study, there was divergence between the APP and the surgeon in only 14/120 cases and when considering the secondary diagnosis, the number of divergent cases fell to 9/120 participants.
FISH was performed on all cases scoring 2+ on HercepTest™ and for quality control purposes on a proportion of the divergent cases from the study group.
The analysis of correlated expression, relative distribution, divergent cases and correlated cases are shown in Figure 3B.
Attention was paid to divergent cases.
Divergent cases were included in analysis.
Divergent cases within each theme were identified and discussed.
The divergent case presented normal expression of the three MMR proteins but microsatellite instability after PCR.
An even more divergent case was found with the discovery of the hyperthermophilic Nanoarchaeum equitans, a tiny symbiont of the crenarchaeote Ignicoccus hospitalis.
We also observed frequent duplication of ESAGs, including a large-scale duplication in BES1 (Tan40), an ESAG7 triplication in BES4/TAR28 and three cases of divergent additional copies of ESAG8 (BES13 BES13 and BES15).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com