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This divergent action is consistent with the pleiotropic nature of SHB as an adapter protein participating in numerous responses [8].
Recently, we demonstrated that at least in macrophages SOCS3 is a key regulator of the divergent action of these two cytokines.
Collectively, these data suggest the low frequency of sudden death observed in Ccnd1 KI/KI mice is complex, and further highlight the divergent action of cyclin D1b on developmental phenotypes.
Recent studies indicate that SOCS3 plays a key role in regulating the divergent action of IL-10 and IL-6, by specifically blocking STAT3 activation induced by IL-6 but not that induced by IL-10 [ 8, 9].
First, extensive in vivo analyses uncovered overlapping but non-redundant functions with that of cyclin D1a, providing the first evidence of divergent action of this isoform on normal cellular processes.
Despite the structural similarities between the insulin and IGF-1 ligands and their receptors, the downstream pathways affected by these two hormones in myoblasts are different in important respects and follow divergent action streams.
Similar(52)
When "The Fall to Earth" is at its strongest, it almost makes these divergent actions believable.
The divergent actions of major central banks – with the US Federal Reserve edging rates up and the European Central Bank reducing them – are likely to add to this uncertainty.
Club owners did not even discuss their surprisingly divergent actions of their individual meetings — the American League's decision to retain the "rabbit" ball next season after the senior circuit had voted for a heavier and slower sphere.
Myeloid cells exert various, often divergent, actions on the immune response through mechanisms that exploit mediators of this peculiar metabolic pathway, ranging from l-arginine itself to its downstream metabolites, like nitric oxide and polyamines.
Because they don't schedule formal meetings or centralize planning, a week of separation can cause divergent actions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com