Most informational genes are highly constrained by interactions with other proteins and evolve slowly (Rivera et al. 1998), which can potentially lead to slower divergence of nucleotide usage patterns.
There is a divergence in usage of Arabic and Roman numerals.
If embryology is divergence of information by differential usage of its genes in the tree of cellular descent from the single ancestral fertilized egg, then evolution is divergence of the information (genomes) among individuals in a tree of descent from a common ancestor.
Second, the differences of divergences, codon usage, and expression patterns between orthologs and paralogs of actin copies within groups and within species indicated that actin genes within groups were highly homologous, but actin genes within species were very divergent.
It has been shown in humans, for example, that genes expressed in ovaries have likely been under slightly greater selective constraint than testes for codon usage following the divergence of humans and mice [ 3].
Furthermore, a divergence in the usage of the term in light of function (e.g. technology parks) and even marketing is observed.
This has led to the suggestion that non-methylated DNA is a unique feature of gene promoters in endotherms, potentially representing a major divergence in the usage of this epigenetic system between warm-blooded and cold-blooded vertebrates (Aïssani and Bernardi, 1991; Sharif et al., 2010).
§ 571.4 Explanation of usage.
The structural divergence of the two RARα isoforms arising from alternative promoter usage and alternative splicing includes differences in functional sub-domains [ 34] which may enable their differential targeting with pharmacological agents.
