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Instead, each of the isoforms has a distinct effect on cell shape, implying divergence of functions.
Because of such divergence of functions, it still remains a challenge to answer "what is the nature of association areas?".
Rtt107, the Brc1 homolog in Saccharomyces cerevisiae, has a very different pattern of genetic interactions, indicating evolutionary divergence of functions and DNA damage responses.
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For the past 25 years, we have developed the enolase superfamily (ENS) as a paradigm to characterize and understand the structural bases for divergence of function in functionally diverse superfamilies.
Perhaps most general of these evolutionary paradigms is the duplication and divergence of function of an ancestral bi-functional gene.
The expansion of CATH superfamilies with sequence data considerably increased the amount of functional data too, allowing large scale studies of the divergence of function within superfamilies during evolution.
Divergence of function in the two nematode PMTs provides two distinct antiparasitic inhibitor targets within the same essential metabolic pathway.
The possibility of divergence of function is suggested by the large variation in pIs among the proteins (3.98 to 5.59).
With this many homologs present, it is likely that there is some amount of redundancy and/or divergence of function.
Multiple copies of genes allow for higher RNA expression under a greater number of conditions and also for divergence of function.
Given the small size of the lipocalin domain and the divergence of function between LCN2 and LCN7, it seems unlikely that any general conserved angiogenic function can be assigned to lipocalin proteins.
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