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It is not yet clear whether these effects are important in vivo; however, they provide evidence for a divergence of effects when n-3 LC-PUFAs are oxidized.
In conclusion, our proteomic study in the brain and cerebellum of 3 × Tg-AD mice show an interesting divergence of effects between these two CNS regions.
Thus, the confluence at MAPK of signals generated by resveratrol and E2 results, downstream of MAPK, in a divergence of effects on nuclear transcription by p53 and by E2.
The main weaknesses include different methods used to quantify sperm count; the paucity of studies that have examined TCDD effects on DSP and the ambiguous nature of those results; the absence of documented changes in testicular and spermatozoa morphology; and the divergence of effects of TCDD upon sperm counts and circulating androgen levels.
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The divergence of effect may be related to a selective increase in desmin-immunoreactive pericyte coverage in the PVN in offspring exposed to dex during pregnancy.
From a therapeutic perspective, such a divergence of effect translates into the balance between ingress and egress of monocytes into plaques requiring a cell-targeted approach, because systemic modulation of netrin-1 would exert an indiscriminate action on different cell types, resulting in opposing effects on atherosclerosis progression.
This divergence of the effects of disruption of ethylene biosynthesis and signalling strongly supports the notion that ACS, and thus probably ACC, has a role distinct from its function in ethylene production.
Again, this is a problem that will disappear if the focus of the paper is recast, so that instead of focusing on divergence of the effects on healthy and stroke brain, it focuses on the need for a narrow window of MMPs.
However in studies investigating the effect of gene conversion on codon use or on patterns of divergence and polymorphism effects of gene length and gene position have not been considered before.
Deletion of SOCS3 in POMC neurons results in increased leptin response and also improved glucose homeostasis, suggesting a divergence between effects of leptin on obesity and glucose homeostasis.
In one example, adaptive differentiation of native insects flushing on invasive plants arose from rapid epistatic divergence of novel, major genetic effects (Carroll et al. 2003).
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