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The issue of a wider biopsychosocial assessment also reflects the divergence of "conversion entities" and their various etiologies: These extend from minor and transient conditions of psychological distress, which might require only reassurance and support, to complex traumatized patients with various co-morbidities, who may require long-term psychotherapy and psychopharmacology.
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It is not clear which would occur more frequently, or where the balance of forces would lie; however, increased divergence would inevitably reduce the probability of conversion between two sequences and less conservative regions of a gene may rapidly escape conversion after duplication, allowing unfettered divergence.
The net effect of conversion among CDSs with divergence among 3'-UTRs is evident in comparative phylogenetic trees.
The divergence among paralogs could also reflect the level of conversion which can homogenize paralogs.
We further propose that sequence similarity has been preserved between these homologues' 5' UTRs by recurrent episodes of gene conversion, despite rapid divergence of sequences elsewhere in their genes.
While the conservation of coding regions provides a situation susceptible to conversion, the functional divergence of non-coding regions has abolished identity, thereby precluding homogenisation by homologous recombination, which would presumably be maladaptive if it were to occur.
Alternatively, the GSIIB genes in C. reinhardtii and V. carteri may have evolved via an early duplication within the Chlamydomonadales with subsequent gene conversion following the divergence of these lineages.
Often these duplicative origins were accompanied by conversion or rapid divergence of gene sequences, and experimental evidence elsewhere suggested that the novelty created by duplication is maintained to satisfy the requirements of particular life stages or for precise regulation of specific amino acids.
However, data are needed from a wider range of species before the effects of duplication, divergence and gene conversion can be rigorously evaluated.
We think that it is important to point out this relationship because it summarizes the significance of the divergence of Bub1 and BubR1 and of the conversion of Mad2.
If gene conversion occurred after the divergence of primates and rodents, those regions would have a higher probability of the type-C tree than that of the type-N tree.
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