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Of the functional categories tested, 10 Cellular Component categories, 20 Biological Process categories and 12 Molecular Function categories showed significant deviations from expected equal proportions of high, intermediate and low divergence categories at the Bonferroni-adjusted α level.
Based on these tests, genes were categorized as conserved, or as belonging to cis-regulatory, trans-regulatory, or cis- + trans-regulatory divergence categories.
For genes in the cis- + trans-regulatory categories and trans-regulatory divergence categories, Chyb and Ehyb alleles were classified according to the magnitude of the variation in allele expression between the hybrid and the parents (fig. 6).
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The absolute magnitude of parental gene expression divergence in each regulatory divergence category was evaluated.
We then extrapolated the fraction of fixed elements in each divergence category to the entire Expander family.
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GACK algorithm does not give information on the degree of divergence of individual genes in the divergent category [45].
Here a new Bayesian statistical approach is used to infer, from patterns of sequence conservation and divergence, various categories of co-conserved residues associated with Arf/Arl GTPase functional divergence.
Zebrafish and medaka maintain two roughly proportional peaks of Ks values (approximate mean values of Ks = 2 and Ks = 4), indicating two broad age (divergence level) categories of duplicated genes in these species, irrespective of duplicate set number.
Applying a mean t-test unambiguously indicates that the mean divergence per category is significantly higher in the enriched library than in the control library, and this for all size categories (Table 1).
Aided by a new approach to correcting for these errors, we performed a comparative analysis of genetic divergence across GO categories among S. crassipalpis, D. melanogaster, and Anopheles gambiae.
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