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Disturbed regulation of this vital process represents a major causative factor in tumorigenesis.
This polymorphism has been linked to various disease phenotypes involving disturbed regulation of dopaminergic neurotransmission [ 9].
Besides centrally disturbed regulation disorders, hyperthermia often results as a consequence of intense skeletal muscle hypermetabolic reaction.
According to the philosophy of differential coexpression analysis [ 24], these links potentially represent the disturbed regulation relationships during disease progression, and therefore are worthy of further investigation.
T cells that are deficient in CD37 have disturbed regulation of T cell receptor signaling leading to increased proliferation (van Spriel et al. 2004).
The pathophysiological processes to explain this relationship are hypercortisolaemia related to e.g. insulin resistance, sympathetic vagal dysbalance related to e.g. disturbed regulation of blood pressure, and an unfavourable lifestyle like cigarette smoking [ 7].
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On the other hand, the inhibition of this enzyme could lead to a disturbance of water homeostasis in the kidneys, mainly by disturbed AQ2 regulation of water channels via adenylate cyclase or the prostaglandin E2 pathway.
The mechanisms underlying a disturbed appetite regulation and overeating are poorly understood.
Taken together, our results add to the evidence of disturbed immunological regulation in patients with narcolepsy.
Similar to other tumours, disturbed epigenetic regulation plays a key role in the pathogenesis of meningiomas.
They require gene expression modification to consolidate information, and disturbed transcriptional regulation could perturb neuronal function and cognitive performance (104).
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