Sentence examples for disturbance of expression from inspiring English sources

Clearly the role of TopBP1 in replication and genome maintenance would mean that disturbance of expression could result in genomic instability contributing towards cancer.

The disturbance of expression of G1/S and G2/M phase cell cycle genes by NCS significantly affected the post-embryonic development of the Arabidopsis roots.

Further, small deletions resulting from ZFN-mediated non-homologous end joining (NHEJ) events are likely to cause little disturbance of expression of neighboring genes, whereas the conventional knockout technology often relies on the insertion of a selection marker, with a higher chance of a neighboring effect.

The DA SH-SY5Y neuroblastoma cells have served as valuable and productive model systems to characterize mechanisms of neurogenesis in vitro and, in the present study, convincingly demonstrate major disturbances of expression in HPRT knockdown cells (Figures 1 and 3).

To further examine possible disturbance of gene expression in the Pygo1/ Pygo2 mutant kidneys, we used microarrays to perform a global analysis of gene expression changes.

In addition, MLN4924 exerted its suppressive effect on protein neddylation in cells, as indicated by a significant decrease in the expression of total Nedd8-conjugated (neddylated) proteins, cullin neddylation and by the increase in free Nedd8, without obvious disturbance of the expression of neddylation enzymes.

We could show that all recombinant viruses grew similar to wild-type and observed no disturbance of protein expression and intracellular localization.

Virus infection affects plant growth and development processes, and the disturbance of gene expression by virus infection may lead to the development of disease symptoms such as dwarfism and mosaic on leaves [1] [8].

Conversely pathological disturbance of the expression of FAK and of its isoforms could lead to abnormal cellular regulation.

Disturbance of the expression of some of these integrins at the surface of EVTs is associated with pregnancy disorders such as preeclampsia [ 5, 11].

We previously demonstrated that air pollution may be one of the risk factors for MtS in this unique geographic location, as evidenced by disturbance of the expression of genes involved in MtS in both in vitro 20 and in vivo.