The distributive activity of human TUT7 is consistent with a recent structural study, which showed that Cid1, homolog of TUT7 in S. pombe, uridylates single-stranded RNA in a distributive manner (Yates et al, 2015).
We conclude that AAG is able to diffuse along both dsDNA and ssDNA but shows distributive repair activity on ssDNA caused by rapidly reversible binding of the lesion site in this context.
Biochemical studies showed that it has decapping activity (toward both GpppRNA and mGpppRNA) as well as a distributive 5′ 3′ exoribonuclease activity, although it lacks PPH activity.
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A novel family of enzymes that possess RNA 5′-end pyrophosphohydrolase (PPH, releasing pyrophosphate PPi), decapping, and/or distributive 5′ 3′ exoribonuclease activity was recently discovered.
Fig. 2A shows no differences in relaxation activities and distributive pattern between this double truncation and the wild type.
Thus, conflicting observations regarding the processive or distributive nature of PRMT1 activity may be partially due to the different substrates used and hence changes in the substrate-induced processivity rate.
The nuclear RNA exosome includes a 9-subunit non-catalytic core that binds Rrp44 (Dis3) and Rrp6 subunits to modulate their processive and distributive 3′-to-5′ exoribonuclease activities, respectively.
The RNA world hypothesis has since triggered research on ribozymes [ 21– 28] to demonstrate various enzymatic activities, including ligases, distributive (but non-processive) RNA-polymerases, nucleases, aminoacyl tRNA synthetases and other types of activities by polynucleotides of up to 300 bases in length.
In general, members of this family of Pols possess a preformed and open catalytic active site compared to well studied high fidelity replicative Pols, are distributive, and lack intrinsic exonuclease proofreading activity (reviewed in [1], [4]).
