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This review addresses the distribution, turnover and tissue-specific properties of HA.
To help reveal their origin, development, spatial and temporal distribution, turnover, occurrence and roles in adaptation to freezing temperatures, extensive studies are necessary (reviewed by Wisniewski et al. 2009).
More recently, the classical structural role of keratins was extended to their involvement in cell signalling, stress response and apoptosis, mostly through their interaction with other proteins and/or their phosphorylation, glycosylation, transglutamination, caspase cleavage and ubiquitination state affecting keratin organization, distribution, turnover and function [ 17].
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Weaker selection implies a more peaked distribution of turnover rates with diminished contributions from both the high and the low turnover rates.
Kwak, Y.T. et al. IκB kinase α regulates subcellular distribution and turnover of cyclin D1 by phosphorylation.
The genomic slots can have an arbitrary distribution of turnover rates.
A large shape parameter results in a sharply peaked distribution of turnover rates and therefore signifies weak selection.
Problems related to workforce development including uneven distribution, rapid turnover and lack of professional development opportunities were also reported by two other studies from Iraq [ 13, 36].
Thus, it does not indicate the distribution or turnover of any specific mitochondrial protein, but rather acts as a marker for mitochondrial matrix protein content.
Unlike models A, B, and C, in which the distribution of turnover rates is parametrized, in model D, this distribution derives from a stochastic population model described in detail in the Materials and Methods section.
It is difficult to use transfection of fluorescently-tagged proteins (β-catenin in this case), as often the levels, distribution and turnover of the recombinant forms can be quite different to the endogenous proteins.
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