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The genomic slots can have an arbitrary distribution of turnover rates.
A large shape parameter results in a sharply peaked distribution of turnover rates and therefore signifies weak selection.
It remains to be explored how the shape of the new gene fitness distribution affects the steady-state distribution of turnover rates.
Weaker selection implies a more peaked distribution of turnover rates with diminished contributions from both the high and the low turnover rates.
Unlike models A, B, and C, in which the distribution of turnover rates is parametrized, in model D, this distribution derives from a stochastic population model described in detail in the Materials and Methods section.
In the neutral model (model A), nothing differentiates the genes, and all slots have the same turnover rate, that is, the distribution of turnover rates is a delta function.
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This assumption translates in practice into the fixed genome size and distribution of gene turnover rates.
Nevertheless, when more plant genomes are sequenced, the hypothesis that plant lineages are subject to higher rate of the U12 to U2 conversion may have opportunity to be tested by looking at the distribution of the turnover rates by comparing various branches of plants.
Among the three examined models with selection, the best fit on average resulted from using the distribution of gene turnover rates produced by stochastic population dynamics with additive per-gene fitness effects in which the fixation of mutant genes was considered explicitly.
Additional file 2: Figure S1 contains the "best" estimates of the fractional turnover rate constants, and Additional file 2: Figure S2 displays the relative distribution of plasma iron turnover fluxes into periphery.
The selection pressure translates into the breadth of the distribution of the gene turnover rates.
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