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The distribution of splice variant 6 was one clone from eight RA patients and two clones from six RA patients.
Ttna and ttnb expression results in a complex distribution of splice isoforms, whose identity and composition vary over early development (Steffen et al., 2007 ).
Assuming the experimental samples come from different individuals, what is the reason to assume that they will have the same distribution of splice mutations?
The experimental sensor performance study is shown in Figure 4. ROC curve irregularities could be attributed to multimodal score distribution of splice and splice-like signal, as could be seen in Figure 3.
Based on the distribution of splice sites near raw sequence tags, the splice sites could be divided into five categories: 0 to 4 (Additional file 1: Table S9 and Fig. 5).
However, neither the transcription start, which was conserved between homozygous dilute (Dc D /Dc D ) and non-dilute (Dc d /Dc d ) individuals, nor the distribution of splice variants in the differentially pigmented skins, convincingly explained the differences in dilution phenotype.
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Moreover, the distribution of 3' splice-site scores for P2 exons (i.e., downstream DAlFEs) was virtually identical to that of upstream DAlFEs (Figure S1B).
These results are compatible with a previous study [49], which showed a highly restricted phylogenetic distribution of splicing events in mammals.
The number and distribution of splicing events for mouse PS genes is shown in Table 2. Orthologous relationships between human and mouse genes were inferred using the information provided by the ENSEMBL consortium.
The distribution of splicing sites per gene is presented in Figure 5A.
Nevertheless, we observed differences in the distribution of splicing events between MSB1 T cells and DT40 B cells.
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