These were distributed across six genes: TP53, STK11, MET, PIK3CA, BRAF and NRF2 and the distribution of mutations across samples are indicated in Figure 1.
Together, the study of these different mutational strands — the good, the bad and the irrelevant — is weaving a comprehensive picture of the general distribution of mutations, and thus, the spectrum of genetic variation that appears in nature.
Data derived from ISOGG consortium (July 2013) Fig. 3 The overall distribution of mutations per haplogroup.
However, this model assumes a uniform distribution of mutations throughout the genome.
The specific coverage of mutations per genes in haplogroups and the general distribution of mutations per haplogroup are illustrated in Fig. 2 and Fig. 3, respectively.
Goodman analyzed the distribution of mutations over the span of amino acids in the cytochrome c sequence by distinguishing several different functional groups.
Citrullinemia type I is a rare metabolic disorder and the distribution of mutations in the ASS1 gene varies among ethnic groups.
These equations are useful in estimating the distribution of mutations, the degeneracy of the library and the frequency of a particular clone in the library.
This influence has helped shape the genomes of humans and other multicellular organisms and can affect the distribution of mutations in somatic cells.
In particular, the distribution of mutations is highly associated with intrinsic molecular processes including transcription, chromatin organization, DNA replication timing, and DNA repair.
The distribution of mutations among the clones and genomic regions is described in Table 2.
