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The CT data were used for attenuation correction as well as for the determination of anatomic distribution of increased radionuclide uptake, and images were reconstructed using a fully 3D iterative algorithm (VUE Point HD).
This study compares the frequency and distribution of increased activity on 18 F-fluoride PET/CT with the presence of bone marrow edema on whole-body MR imaging in the spine and sacroiliac joints (SIJ) of patients with active ankylosing spondylitis (AS).
The subgroup analyses found that the MDD patients with moderate-to-severe resistance (n = 8) also had significantly higher 18F-florbetapir SUVRs than the HCs in the frontal area and showed the similar regional distribution of increased 18F-florbetapir uptakes (n = 9) (data not shown).
The ASM, Correlation, IDM and Entropy showed no significant difference between MOH and NC. Figure 2 presented the distribution of increased Contrast in MOH patients, and the other texture parameters showed no significant change in MOH patients compared with NC patients.
Fig. 1 Spatial distribution of increased 18F-florbetapir SUVRs in the MDD patients with differing levels of treatment resistance as compared with the healthy controls (HCs), as examined by statistical parametric mapping (SPM) analysis, with an uncorrected P < 0.01 and clusters consisting of a minimum of 100 contiguous voxels, which were considered to indicate a significant difference.
Visual inspection shows a wide distribution of increased lower frequencies in both patients groups in comparison to controls.
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Three different permeability distribution of increasing downward, random and increasing upward have been considered.
Thus, the distribution of increasing and decreasing pairs should be significantly different from the binomial ("no effect") distribution with a particular p-value (usually 0.05).
In simulation tests with systematic distribution of increasing upward, the permeability of layers increases within lower part towards the upper layer.
However in cases with systematic distribution of increasing downward, the layers permeability increases from upper to the bottom layer of the model.
The distribution of increasing neuropathy symptoms in patient groups stratified by the severity of clinical neuropathy is given in Fig. 1.
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