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Middleware is a software layer typically between the operating system and the distributed applications, transparently providing interoperability, distribution of functionality, scalability, load balancing and fault tolerance for the applications.
The distribution of functionality will occur across swarms of connected devices: referred to as wearable devices (when attached to our bodies) or the Internet of Things (when dispersed throughout our environment).
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The distribution of functional groups (functionality maps) on the substrate binding site allows for identification of modifications of the tetrapeptide sequence that are consistent with potent peptidic inhibitors.
To study distribution of fluorogenic functionality in individual F-spores, we used F-spores of B. megaterium (ATCC No. 14581) constructed with Syto 9.
The distribution of gene functionality was analyzed based upon the Cluster of Orthologous Groups (COGs) protein database [ 33].
This new tool enables researchers to easily assess the distribution of GPCR functionality in diverse genomes or individual newly-discovered proteins.
This local component in the distribution of the functionality across chromosomes is probably affecting the own chromosomal architecture by limiting the possibilities in which genes can be arranged and distributed across the genome.
As observed in the distribution of nonsynonymous functionality scores, the RNA scores of RNA nodal mutations (i.e., either RNMs or SNMs, fig. 1 D) had significantly lower values than that of disease-causing mutations (Mann–Whitney U test, P < 0.001).
Regardless of the fact that some recent evidences link chromosomal physical location to function [ 4, 5] and that disease-related genes have been recently described as mapping in adjacent positions in the chromosomes [ 6- 8], the putative impact that this local distribution of cellular functionality could have in the symptomatology of diseases that harbor CNAs still remains largely unexplored.
PMOs have well-defined pore sizes and pore shapes, high specific surface areas and uniform distribution of the functionalities [5].
Besides the basic distribution of C functionalities, application of solid-state NMR allows the implementation of specific experiments dedicated to evaluate the steric arrangement and conformational behavior of crystalline and amorphous polymers [11, 12].
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