To address the reviewer's concern, we prepared figures showing the distribution of docked vesicles relative to dense projection at different time points after stimulation (Reviewers' figure 1).
According to our experience, all the distributions of docking scores in CPI correspond to normal distribution if the data points (docking score >0) are excluded.
Light-microscopic studies in reduced systems indicate that distribution of essential docking factors is complex, with accumulations of individual factors in partially overlapping microdomains (Lang et al. 2001; Lang and Jahn 2008).
We present a model of hyphal tip growth in which secretory vesicles fuse to the plasma membrane at a rate proportional to the local concentration of Exo70 and Sec3, which, based on concurrently available evidence in both S. cerevisiae and C. albicans, determines the distribution of vesicle docking.
A good separation was obtained for the medians of docking score distribution for actives versus inactives confirming that the actives are enriched.
Distribution of the native ligand docking results (absolute and relative quantities) by quality is shown in Table 1.
After computational docking, the distribution of calculated binding energies suggests that, statistically the flat compounds from Set 2 fit more snugly on the flat surfaces of Aβ16 21 fibers than those with diverse shapes in Set 1.
The primary objectives investigated within this study are to find a strategy for a model-based distribution of charging-stations, to implement docking-stations and electric bicycles, and to analyze the mobility patterns of possible customers.
Electronic monitoring of the bikes can show ebbs and flows of bike traffic through cities, allowing better distribution of bikes and planning of new docks.Just as mass public transport changed the development of cities' suburbs, bike-hire schemes are now shaping city centres in subtle ways.
We conducted an independent set of docking experiments on snapshots from the two bound ANT1/ADP simulations and fit normal distributions to the binding energy histograms obtained from these experiments.
