In contrast with the distribution of topoisomerase I which is located primarily at puffs, the Drosophila topoisomerase II is distributed generally along the chromosomes paralleling the distribution of DNA itself.
(a) Distribution of DNA inaccessibility scores.
The distribution of DNA transposon density across chromosomes: DNA transposon length/5 Mb.
(a) Distribution of DNA accessibility scores and H3K9me2 enrichments (red, high data point density; blue, low density).
The phylogenetic distribution of DNA repair genes has been discussed in detail by Eisen and Hanawalt (1999), while Aravind and Koonin (2000) have specifically analysed the UDG superfamily.
The distribution of DNA barcodes across infected snails and sampled locations revealed a complicated spatial sub-structuring.
Further, the size distribution of DNA fragments showed a significant dependence on radiation quality, with an excess of fragments up to 1 Mbp.
The results suggest possible roles of both track structure and chromatin organization in the distribution of DNA double-strand breaks along the chromosome.
In our data, the overall distribution of DNA methylation was almost similar between RA and OA, which is in discord with previous observations showing prominent global hypomethylation in RA synoviocytes38,39.
Our knowledge about the genome-wide distribution of DNA methylation, how it changes during cellular differentiation and how it relates to histone methylation and other chromatin modifications in mammals remains limited.
The realization that nuclear distribution of DNA, RNA, and proteins differs between cell types and developmental stages suggests that nuclear organization serves regulatory functions.
