Because the geographic distribution of diseases caused by the agents is generally characterized by the distribution of the tick vectors, these findings provide insights regarding the distributions and endemicity of several potential emerging tick-borne agents.
The distribution of inhaled mineral fibers in the lung determines the site and severity of disease caused by the fibers.
Changes in distribution of disease-causing serogroups within regions is unpredictable and can occur over relatively short periods of time.
Understanding what kind of genes are most likely to harbor disease-causing mutations, when the disease-causing alleles originated, why these disease-causing mutants segregate in human population, and how natural selection shaped the distribution of disease-causing mutations in the human genome is of great interest.
Overall regional conservation, which takes into account the average variability per site in a domain, contributes to the uneven regional distribution of disease-causing mutations in some proteins [ 25], but we found this only for KCNQ1.
Other goals are measurement of vaccine efficacy, assessment of whether the vaccine is interrupting transmission, and evaluation of the distribution of serotypes causing disease (to determine if decline in disease because of serotypes included in the vaccine has been counterbalanced by emergence of invasive disease caused by nonvaccine serotypes).
Figure 1 displays the distributions of these five features for benign and disease causing mutations; Table 2 contains the corresponding F-scores and pairwise correlation coefficients.
11, 12 The distribution of serogroups causing disease has also shifted.
Despite the introduction of pneumococcal conjugated vaccines, S. pneumoniae remains a major cause of morbidity and mortality worldwide, mainly due to the different distribution of serotypes causing disease or replacement of vaccine serotypes.
Due to the world distribution, host range and the interaction with other plant disease causing agents in the disease complexes, they are considered as one of the most important plant pathogens which threat world food resources.
The observed association with disease genes, hypermutability and wide distribution of STRs suggests that STRs in exons may be good candidates to screen for rare disease causing mutations.
