The distribution of highly differentiated mitochondrial cytochrome b haplotypes was not concordant with the morphological and nuclear characters.
More specifically, the adult cartilage tissue has a limited self-repair potential "due to the sparse distribution of highly differentiated, nondividing chondrocytes, slow matrix turnover, low supply of progenitor cells, and lack of vascular supply" [ 7].
Importantly, while normal intestinal renewal follows a random, patchy pattern of tissue replenishment (e.g. Fig 3A), escargot loss or the ectopic expression of the mir-8 microRNA resulted in a homogeneous, salt-and-pepper distribution of newly differentiated cells (Fig 3B and C).
The distribution of 8% well differentiated, 50% moderately differentiated, and 42% poorly differentiated adenocarcinomas correlates well with a previous series of 55 FMAs [ 39] in which 14% were well differentiated, 60% were moderately differentiated and 27% were poorly differentiated.
The distribution of the highly differentiated RNAseq loci across the genome was not random.
Overall, well-differentiated neoplasms have a higher density and more homogeneous distribution of SSTRs than poorly differentiated endocrine carcinomas, except for SSTR5 that shows the opposite trend.
The characteristic punctate distribution of GAD65 along neurites of differentiated cultured hippocampal neurons was significantly reduced after excitotoxic injury, and the total GAD activity measured in extracts from the cerebellum or cerebral cortex at 24h postmortem (when there is a partial cleavage of GADs) was also decreased.
Recognizing the differentiated distribution of LMX relationships within a team, previous studies have uncovered the dark side of LMX differentiation (Henderson, et al., 2009).
Knockdown of JAG2 did not affect the relative distribution of proliferating progenitors and differentiated neurons in the spinal cord, neither changed the identity of progenitors along the DV axis (Supplementary Figure 2 and data not shown) similar to the results recently reported for JAG1.
It was noted that highly undifferentiated tumours have a very patchy distribution of K8 whereas more differentiated tumours have a pattern where cells along the mucosal surface were more positive for K8 and deep cells were either negative or showed less K8 expression.
