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The use of periodic assemblies of graphene nanoribbons seems also a design feature that could lead to potential breakthroughs in terms of mass-sensors concepts, with enhanced selectivity provided by the periodic distribution of constraints and supports.
The distribution of constraints in introns moving away from the splice sites, however, indicates that the regions under strong constraints in rice are quite short, only about 10 bp at the 5' end and even shorter at the 3' end (Fig. 4).
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Although these only represent a small fraction of the total number of pairs of individuals compared across all populations, it shows that the framework of comparing distributions of constraint scores on the individual level is able to detect significant differences, even for supposedly 'healthy' individuals from the 1000 Genomes populations.
Table 18 Case process summary of multinomial logit analysis Case processing summary N Marginal percentage What is the distribution of credit constraints?
Table 19 Parameter Estimates (Multinomial Logit Analysis) Parameter estimates What is the distribution of credit constraints?a B Std. error Wald df Sig.
Two plausible scenarios might explain such a distribution of selective constraints in biosynthetic pathways.
Since the distribution of NMR constraints over the sequence has no significant gaps, we can conclude that this structure is a reliable representation of the structure in solution.
Therefore, the polarity in the distribution of selective constraints along the pathway is neither incidental nor specific to the Drosophila genus, suggestive of a more general biological mechanism.
The same reasoning applies to other biosynthetic pathways with a similar distribution of selective constraints (Sharkey et al. 2005; Livingstone and Anderson 2009; Ramsay et al. 2009).
Therefore, although the biological mechanism underlying this gradient distribution of selective constraints remains elusive, it is likely to be similar between Drosophila and vertebrates.
A heterogeneity index is introduced to quantify local variations in constraint density to investigate the impact on the VPG results when there is greater or lesser degree of spatial variance in the distribution of distance constraints within a network.
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