The distribution of batch sizes is assumed to be uniform.
Indeed, it is not possible to identify precisely individuals who were exposed to SV40, as few vaccine batches were tested for contamination, not all batches were contaminated and distribution of contaminated batches from one country to another was not controlled (Gazdar et al, 2002).
Table S1 details all products included in the study, their presentation, license number, maker, distributor, and the distribution of their batches for in vivo, in vitro, or both kinds of experiments.
Batches were categorised into lesion present/absent using the frequency distribution of the batch prevalence for the different pathologies to determine data-derived cut-off points (further details are provided in Additional file 1: Figure S1 and Figure S2).
We emphasize the no-wait condition between the production and distribution of each batch, and prove that the general version of this integrated operational scheduling problem is strongly NP-hard.
The period of distribution of 1 batch matched the estimated period of contamination of nonsecondary cases.
We found that careful inspection of the DNA size distribution of each batch of chromatin was useful to prevent further processing of low quality samples.
We examined the features of the overall resulting data set, including the range and distribution of the batch-processed BMD and BMDL values.
Thus, the observed quality factor is probably not suffering substantially from the finite size and shape distribution of the nanocrystal batches synthesized here, but it is rather determined by the nanocrystals surface properties, damping the LSPR resonance by surface scattering of free carriers.
Reproducible, large-scale synthesis of nanomedicines is still a challenge for the distribution of a homogeneous batch of nanomedicines, especially when considering that these nano-platforms often require specific conditions for production via self-assembly.
