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After removing these well-validated associated loci, we observed little statistical inflation in the remaining distribution of association statistics (inflation factor λgc = 1.047; Supplementary Material, Fig. S1B).
In contrast, for PHF6 a broad and divergent distribution of association states was found.
The distribution of association signals for HDL-C is shown in Figure 1A, and lead SNPs for loci showing experiment-wide significance (i.e. FDR q≤0.05) in Table 2.
Although there are several methods to control for population structure in association mapping that were also applied here [31], it is still useful to estimate the extent of false positives using a null distribution of association tests P-values from a random set of markers.
The distribution of association signal varies between diseases.
Overall the distribution of association P-values was consistent with a null distribution.
Similar(37)
Although there was no difference in the distribution of associations between p17 (n = 3) and p24 (n = 10) (two-tailed Fisher's exact test p = 0.55) if we took into account the respective lengths of p17 and p24, the larger number of HLA-mediated associations in p24 may be associated with the efficient control of viral replication ascribed to p24-specific CTL responses.
The distribution of association-weights for the aging concept had a maximum score indicating that the common genes between OPMD and elderly indeed represent well-known aging genes.
The distribution of associations for the different regions is given in Table 1, and depicted in Fig. 3.
Further, the groups significantly differed by distribution of the association between age and telomere G-tail length (Fig. 1A), and also significantly differed in the distribution of associations with total telomere length and telomere G-tail length (Fig. 1B).
Our study showed that the distribution of associations between telomere G-tail length and total telomere length were significantly different from that in control subjects.
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