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Firstly, a hybrid vertical mutation operator is carefully designed, which can escape local optima and conduct a local search by uniform distribution mutation and Gaussian distribution mutation, respectively.
Sequences were simulated down the tree using the general time-reversible (GTR) model, while also allowing for a heterogeneous (four-category gamma distribution) mutation rate among sites.
Sequences were simulated down the tree using the general time-reversible (GTR) model and empirical base frequencies, while also allowing for a heterogeneous (four-category gamma distribution) mutation rate among sites.
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Most studies on CFTR mutations, conducted in Asia, have focused on European mutations and confirmed various distribution of mutation in Asia, compared to other continents.
The C and D populations had the same distribution of mutations with 4% truncation mutations, 44 45% missense, and 51 52% silent mutations.
Instead, the target of selection is an optimum distribution of mutation rates, a 'mutational quasispecies'.
However, the transition/transversion ratio was estimated to be 1, indicating a non-random distribution of mutation frequency.
What is the distribution of mutation effects on the adapters?
Table 6 provides the distribution of mutation associations after the labeling.
A graph summarizing the distribution of mutation types is shown in Fig. 1.
The chi-square test was used to compare the distribution of mutation frequencies in cell lines and tumors.
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