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It is quickly distributed into tissues with a distribution half-life of approximately 6 minutes.
However, pharmacokinetics of BTZ are well known as the drug has been shown to be rapidly distributed into tissues after administration of a single dose, with an initial plasma distribution half-life of less than 10 minutes.
The distribution half-life is 9 h and the MRT is 4 h.
The distribution of bergapten into the tissues was slow and this is indicated by the long distribution half-life, T1/2α of 2 h.
The long distribution half-life could explain the reason for high bioavailability in rats after oral administration (T1/2α (h) = 9.35 ± 3.06).
Blood analysis yielded a distribution half-life of 1.2 h (SD 1.5) and an elimination half-life of 26.9 h (SD 2.7).
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Alfentanil is such a short-acting opioid (maximum effect within 1 2 minutes and subsequent distribution half life values of 1 and 14 minutes) [ 24].
At the tested oral dose of 10 μg/g, 20 μg/g and 30 μg/g in three independent experiments, the distribution half life (T1/2α) of enrofloxacin in serum was 6.098 h, 4.186 h, and 4.348 h, respectively.
Based on pharmacokinetic (PK) parameters of individual carbapenems in healthy adults, data on changes in the respective blood concentrations in 2000 cases were simulated by applying a lognormal distribution to probability distributions of their volume of distributions and half-life periods.
To investigate the pharmacokinetics of a 20 mmol magnesium bolus in regards to serum and urinary magnesium concentration, volume of distribution, and half-life.
Our specific aims were to: 1. establish the contraceptive efficacy of PEGLA following vaginal delivery in mice; 2. determine whether bone and the central nervous system (CNS) are non-uterine targets of PEGLA in mice and 3. to compare the tissue distribution and half-life of PEGLA following IP injection and vaginal application in mice.
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