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Here, to dissect miRNA haplotype diversity and distribution, evolutionary pattern across the animal kingdom, miR-17 and miR-124 families were analyzed as special populations.
Still, we understand little about the taxonomic distribution, evolutionary history or function of this trait.
In 2006, we reported a systematic analysis of this gene organization focusing on structural features, chromosomal distribution, evolutionary conservation, expression correlation and functional association among involved genes (4).
MicroRNAs (miRNAs) have made quite a clatter since their widespread eukaryotic distribution, evolutionary conservation, and biological significance have become apparent in recent years [ 1, 2].
In this study, we evaluated distribution, evolutionary history, and function of indels found by comparing syntenic regions of the human and chimpanzee genomes.
Consequently, bioinformatic prediction of functional phosphorylated residues will require utilization of additional parameters that may include, but not limited to, protein kinase consensus sequences, subcellular distribution, evolutionary conservation and polymorphic variability (35).
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Hence, it is a powerful strategy to analyze miRNAs as a special population across the animal kingdom to study haplotype distribution and evolutionary network to infer potential evolutionary history, pattern and trend in the miRNA world.
By varying the mean and standard deviation of the distribution of evolutionary rates, we varied the amount of evolutionary distance between the taxa of our chosen tree topology.
Clearly, this model of evolution implies the conservation of the genome-wide distribution of evolutionary rates without requiring that the absolute evolutionary rates remain constant (the definition of the MC).
This finding supports our previous conclusion that short-term variation plays a major role in the extant distribution of evolutionary rates but tends to average out over longer evolutionary spans (Snir et al. 2012).
In contrast, the universal log-normal distribution of evolutionary rates of orthologous genes seems to require purifying selection as an intrinsic component of the underlying evolutionary model (Lobkovsky et al. 2010).
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