Sentence examples for distribution efficacy from inspiring English sources

Off-target binding can significantly affect the PK, tissue distribution, efficacy, and toxicity of therapeutic antibodies.

Since prodrugs might alter the tissue distribution, efficacy and the toxicity of the parent drug, prodrug design should be considered at the early stages of preclinical development.

The α1-AR family consists of three subtypes, α1A, α1B and α1D, which differ in their subcellular distribution, efficacy in evoking intracellular signals and transcriptional profiles.

We note that these recommendations require time and effort and therefore encourage research on workload distribution, efficacy, implementation, and cost benefit, given the fundamental value of medication safety.

A Gaussian distribution provides efficacy while minimizing the possibility of generating a tumor hot spot.

We now provide a developmental opportunity to employ these novel particles for theranostic drug distribution and efficacy evaluations.

Although pharmacokinetic data and survival statistics from clinical trials provide insight into distribution and efficacy, many details of the mechanism of action remain unresolved, despite the importance in translating liposome-based drug delivery systems to other molecules and cargo.

This would have a profound effect on their distribution and efficacy in vivo and may merit further study.

Agents that reduce tumour IFP have been shown to improve drug distribution and efficacy in pre-clinical and clinical settings [ 43- 45].

Preclinical CNS distribution and efficacy studies using inflammatory animal models of PD (i.e., the two-hit model) will be sufficient to warrant clinical trials on these drugs.

In addition, several formulations of α-TOS have been tested in order to improve its distribution and efficacy at the target site.