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The distribution and disposition of a drug in the body result from a complex set of physiological processes and biochemical interactions.
Physiological response modeling can account systematically for interspecies variations in the distribution and disposition of chemicals in relation to external measures of exposure.
Building a barn, voting on a government, or creating a local budget all imply different meanings of the term 'resource' and in each case its production, distribution and disposition will differ.
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A brief overview on the cellular and organismal distribution and disposition-kinetics of the two drugs is also given.
The characteristics of diversity, distribution, type and disposition of landscape material resources in Mt. Lushan were analysed in this paper, on the basis of extensive investigation, collection and sifting.
This initial selection of transporters was mainly directed by the guidelines of the International Transporter Consortium [27] membrane transporters considered to have a role in drug absorption and disposition (distribution and elimination), therapeutic efficacy and safety (i.e. toxicity) were included.
Pharmacomicrobiomics is an emerging field that investigates the interplay of microbiome variation and drugs response and disposition (absorption, distribution, metabolism and excretion).
Lumefantrine absorption and disposition pharmacokinetics were best described using first-order absorption with lag-time followed by a two-compartment distribution model (Fig. 1).
This phenomenon, target-mediated drug disposition, leads to saturable distribution and elimination kinetics, with substantial BSV.
Table 2 shows the final distribution of disposition codes for the unweighted non-migrant gross sample, separated by migration status (operationalized by citizenship).
We used the final distribution of disposition codes for the unweighted German gross sample, separated by citizenship.9 For comparison purposes, a differentiation similar to that in the technical report for the overall population (Zabal et al. 2014, p. 76) was chosen.
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