In peripheral blood smears, neutrophils were examined in terms of hypersegmentation, nuclear abnormalities (a nucleus with hook, lump, flag-like projections or microlobes and pseudo Pelger–Huet anomalies), cytoplasmic abnormalities (hypogranulation or agranulation and granule distribution abnormalities), and membrane abnormalities (protrusion, loss of integrity).
Due to the distribution abnormality and sample size, non-parametric statistics were used.
Exogenous testosterone after castration alters tumour distribution and characteristics and suppresses epithelial proliferative abnormalities.
As observed in A-EDMD patients, myonuclei in lmna-null mice exhibit both structural and antigen distribution abnormalities (e.g. LAP2, lamin B, emerin).
Smears with 2 % or more damaged nuclei was considered a nuclear structural defect, smears with 2 % or more hypogranulation was considered agranulation, smears with granule distribution abnormalities were considered cytoplasmic granule defects and smears with loss of membrane integrity were considered membrane abnormalities.
This holds especially true, since clinical and experimental research has clearly shown that distribution abnormalities in vasodilatory shock states contribute to significant changes in microvascular hemodynamics [ 5].
HIV-related fat distribution abnormalities, commonly associated with lipid disturbances, have been described in the past as more frequent in women [ 15].
In multivariate logistic regression modeling, fat distribution abnormalities due to ART were an independent risk factor for subsequent non-adherence in adults [ 5].
This finding is in line with that of the Asian cohort reported by Aurpibul et al., which found an increasing prevalence of fat distribution abnormalities as cumulative exposure to ART increased [ 11].
Key findings may be the extensive distribution of abnormalities and the absence of cardiomegaly, lymphadenopathy or beading of the fissures.
In the evaluation of dysplastic findings performed by counting 100 neutrophils, defective nucleus (7.4 ± 2.9 vs. 1.8 ± 1.6), granular distribution abnormality (2.7 ± 4 vs. 0.9 ± 1.3), and cytoplasmic membrane protrusion (0.8 ± 0.7 vs. 0.03 ± 0.2) were found with a higher rate in the study group (p < 0.05).
