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Bioclipse DS has previously been demonstrated on predictive modeling in drug safety assessment [38] and also been linked to invoke and present results from distributed toxicity predictions from the OpenTox infrastructure [37].
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A spatial comparison analysis and regression model indicated that the distributed pattern of sediment toxicity was likely related to hydrodynamics and circumfluence in the East China Sea (ECS) shelf.
Other, less frequent, adverse events were widely distributed and probably represent the toxicity of the background combination as well.
Acute and late skin toxicity of radiation schedules are documented in Table 3. Grade 2 acute skin reactions of were doubled (12 vs. 25 patients) at the second radiotherapy session while acute grade 3 toxicity was inversely distributed (five vs. two patients).
Other non-haematologic toxicities were similarly distributed between the arms.
Other symptomatic toxicities were equally distributed between the two treatment groups.
The variation was evenly distributed in both control and Paraquat toxicity classes.
For longer intervals, when the drug has been distributed to tumour tissue, direct cell toxicity becomes more important (Chen et al, 2006).
Data was collected from the distributed ISSCAN Database (part of structure-searchable toxicity DSSTox public database network [58]).
Occurrences of grade I or II late toxicity proved to be equally distributed.
Most of the conventional chemotherapeutic agents have poor pharmacokinetics profiles and are distributed non-specifically in the body leading to systemic toxicity associated with serious side effects.
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