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Based on the characteristics of gas flow (i.e., gas migrates along discretely distributed pathways and is influenced by the stress state) and the modified gas pressure dependent permeability method from literatures, a modified approach with consideration of stress state was established.
Common and unique reactions associated with distributed pathways could be identified as composite glyphs in the Pathway Tools genome browser (Additional file 1: Figure S4).
Thirty distributed pathways were identified in pair-wise genome combinations that were not predicted in PGDBs for individual cellular organisms using set-difference analysis (Additional file 1: Table S11).
More precisely, the mechanisms underlying the neuroplasticity has been variously attributed to redundancy (parallel distributed pathways), changes in synaptic strength, axonal sprouting with formation of new synapses, assumption of function by contralateral homologous cortex, and substitution of uncrossed pathways [ 36].
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The HD circuit would be thus best described by a distributed pathway, with ADn playing the role of a central hub for HD information (Fig. 5).
Naturally, such intercellular signalling pathway would operate in parallel to a slower and more widely distributed pathway that requires activation of mGluR (metabotropic glutamate receptor) and Ca2+ release from the ER in perisynaptic astroglial compartments.
Our finding that bacteria sense damaged kin and respond via a widely distributed pathway to mount a complex response raises the possibility that danger sensing is an evolutionarily conserved process.
Bacteria resident in the human gastrointestinal tract collectively encode a distributed pathway of BA modification, the products of which are the natural ligands for FXR, 2 and there is growing appreciation that this may be a key activity through which the gut microbiota integrates factors relating to diet and mucosal inflammation, to initiate or exacerbate disease.
By comparing pathway recovery for individual reference genomes to pathway recovery for combinations of reference genomes, it becomes formally possible to use Pathway Tools to identify distributed metabolic pathways that emerge between multiple interacting partners.
Importantly, Ras1CA overexpression in the PSG upregulated many DEGs distributed in "pathways in cancer", "insulin signaling pathway", and "MAPK signaling pathway" as well as "purine metabolism" and "pyrimidine metabolism".
Using Illumina-Solexa sequencing to analyze DEGs in the PSG, here we found that many Ras1-induced genes are distributed in "pathways in cancer", "insulin signaling", and "MAPK signaling pathway".
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