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Holmes's refusal was a distressing blow and caused a period of reflection at Johns Hopkins on the outlook for the entire endeavor.
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Rockets still blow up with distressing frequency and, although machines may have made a small step towards the planets, the idea of humans following them there still looks like a dangerously giant leap.
A nearby stretch of banana plantation had been cleared for carpentry and set-building, and crew-members with blow-torches were busily distressing a fleet of rustic-looking canoes that had been carved from hollowed-out tree-trunks.
Then blow me down, later on, after all these distressing voices, he starts talking to me in a quiet voice.
Unite will be doing everything possible to mitigate these job losses which are a hammer blow to the UK's IT sector and very distressing for employees in the run-up to Christmas".
Besides the fact that describing areas of the human body as having an "erotic function" is one of the most distressing things a government official has ever said, the proposed ban is obviously a huge blow to constitutional freedoms.
And a distressing solipsism..
It was distressing.
He found competition distressing.
A distressing development.
It can be distressing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com