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Myofibroblasts rapidly produce excessive amounts of ECM and exert tractional forces across the ECM, resulting in the distortion of tissue architecture.
Although fibrosis is an essential response to acute cardiac tissue injury, prolonged myofibroblast activation and progressive fibrosis lead to further distortion of tissue architecture and worsened cardiac function.
At center 1, the most decisive parameter for differential diagnosis was distortion of tissue architecture (sensitivity, SN, 83%; specificity, SP, 92%) and, at center 2, relation to the adjacent tissue (SN 93%, SP 92%).
Surgery for recurrent pelvic malignancy is hampered by the distortion of tissue planes and associated scarring.
Strain elastography is technically distinct from transient elastography, using a conventional ultrasound transducer to collect signals with and without distortion of tissue.
Microscopic evaluation of liver tissue from vehicle treated rats revealed profound hepatocellular apoptosis, bile duct duplication and panlobular mononuclear leukocyte infiltration with cytoplasmic vacuolization and severe distortion of tissue architecture (Fig. 4A,C).
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The pain associated with inflammation results in part from the distortion of tissues caused by edema, and it also is induced by certain chemical mediators of inflammation, such as bradykinin, serotonin, and the prostaglandins.
Although distortion of tissues is inevitable during dissection, biomedical imaging techniques such as CT and MRI provide visualizations of internal structures in situ, preserving their geometries and relative positions.
AGE interaction with intra- and extracellular tissue structures leads to distortion of normal tissue architecture [ 23], resulting in (micro- vasculature basemicro- vasculaturekening with reduced vascular wall elasticity, reduced filtration rate across the vessel lumen and diminished arteriolar vasodilatory response all contribasemento tissue ischemembrane, 38].
US elastography is a newly developed dynamic technique that evaluates the degree of distortion of a tissue under the application of an external force and is based upon the principle that the softer parts of tissues deform easier than the harder parts under compression [ 20].
b HUS of the right breast with an irregular lesion and surrounding distortion of the tissue.
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