Sentence examples for distorting expression from inspiring English sources

We note that RNA amplification can double the relative noise in microarray analyses by distorting expression ratios between control and experimental tissues [ 47]; thus, we cannot be sure that all downregulated genes identified by the array would have sufficiently different expression levels between wild-type and spt tissues to be detectable by in situ hybridization.

While this approach has led to the discovery of many imprinted genes, and to the refinement of phenotypic analysis of the consequences of disruptions in imprinting, not all genomic regions are covered by uniparental disomies, and there is a risk that such aberrant genome configurations may distort expression patterns.

Following amplification, PCR products were evaluated by gel electrophoresis to confirm that the appropriate range of molecular weights had been produced (0.5 3 kb), and that the libraries were not over-amplified (i.e., more than 200 ng PCR product per 30-μl reaction), which can distort expression profiles and lead to adaptor concatenation.

This has the consequence of distorting the expression ratios, as clearly demonstrated by our data.

If only I had been trained to follow rules, rather than having been spoiled by the modern disrespect for them!" But if you imagine a cynical expression distorting my face while I read such wistful counterfactuals, you would be wrong.

Psychiatric illnesses remain of unclear etiopathogenesis and a variety of them can coexist, partly mimicking each other while contributing to and distorting symptomatic expressions.

Culture-specific selection pressures also distort the expression profile of LCLs as they adapt to culture conditions [51].

Thus, manipulation of genes involved in dosage compensation can potentially result in female lethality by distorting X-linked gene expression dosage.

A second implication of this study is that one important limit on the use of amplification techniques for single cell expression profiling is that if amplification efficiency drops significantly below 90% then the sampling effect may considerably distort the measured expression profile.

We reasoned that the high abundance of hemoglobin might interrupt the target mRNA binding, or contribute to pseudo-binding (a nonspecific, background signal that is present in the absence of any significant sequence similarity) to the probe, and, therefore, distort the true expression signal.

For example multiple reads from repeat regions such as Long Interspersed Nuclear Elements (LINEs), Short Interspersed Nuclear Elements (SINEs), and ALUs in the untranslated regions of the transcriptome can distort the true expression level.