Similarly, the strains in infant #3 and in early samples from infant #5 are almost identical (a single SNP in the surveyed gene set distinguished the sequences).
When they work properly, auditory magnocells track rapid fluctuations in sound frequency and amplitude; the subtle cues that enable you to distinguish the sequence in which sounds occur.
However, for mapping chromosomes in mitosis in the same material, the minimum resolution required to distinguish the sequences was 2 Mb (Cheng et al. 2002).
This process involves extensive genomic rearrangements, including the physical loss of a large fraction of duplicate regions, and the accumulation of mutations that distinguish the sequences of the duplicate 'homoeologous' copies and contribute to their functional divergence [ 7- 9].
This is a convenient way to distinguish the sequences that are representative of the core of a cluster (i.e. they entered the hierarchy at a low d value), from outlier sequences that entered at a greater d value.
It is important to differentiate between homologous regions that are under functional constraint and those that are similar because they have not had enough time to accumulate enough mutation to distinguish the sequences.
A binary vector s i = (s i,1, s i,2,..., s i, k ) for each sequence s i is created, marking an element s i, k where k is the number of words used to distinguish the sequences with k ≤ | W wc |.
B. napus Q-PCR primers were then designed to a variable region that distinguished the BnGL3 sequence from the AtGL3 and BnEGL3 sequences (Additional file 2: Table S1A).
In other words, it is possible, at least to some extent, to distinguish the test sequence from other sequences when the footprints that are present in the test sequence are used to build the training PWM.
In particular, they all show the same rifampicin-resistance mutation (D435G) in rpoB that distinguishes the XDR sequence from the MDR sequence (D435Y).
