It has potential as an objective outcome measure, for distinguishing symptomatic from asymptomatic cuff tears and as a tool for surgical or therapeutic decision-making.
Some of the challenges of gene therapy clinical trial design are similar to those in studies of conventional pharmacological agents and include addressing the heterogeneity of the disease, the need for clinical and surrogate endpoints, and the issue of distinguishing "symptomatic" from "neuroprotective" effects.
However, the reaction and sensitivity of the bowel to the altered intestinal environment seems to be factor distinguishing symptomatic and asymptomatic patients [ 18].
We were unable to distinguish symptomatic VTE and incidentally detected VTE as the information were not routinely captured in a claim database.
These studies, however, do not distinguish symptomatic and asymptomatic grades of haemorrhagic transformation, and thus their relevance to clinical outcome is unclear.
In future studies we plan to compare Ct values in patients and healthy controls with the aim of identifying cut-off values that distinguish symptomatic and asymptomatic infections.
Currently, there is a registry that distinguishes symptomatic from asymptomatic women, but both groups continue to be served by the screening program.
Pediatricians and physiotherapists have to distinguish symptomatic asymmetry (SA) from idiopathic asymmetry (IA) when examining young infants with a positional preference to determine the prognosis and the intervention strategy.
Case-control studies require adequate case identification, eligibility criteria for equal access of cases and controls to screening, distinguishing symptomatic and diagnostic tests, and adjustments for self-selection bias [ 1].
Similarly, in long QT syndrome, the genotype of a missense polymorphism (Lys897Thr; rs1805123) in the KCNH2 gene appears to distinguish symptomatic from asymptomatic individuals carrying a low-penetrance Ala1116Val pathogenic mutation (Crotti et al. 2005).
