It is also possible that the frequencies of self-reactive T cells might peak near the time that disease is diagnosed and decrease afterwards so that autoreactive T cells in long-term T1D patients (like those recruited for this study) could decrease to levels that are only subtly different from non-T1D subjects and difficult to distinguish regardless of the assay used.
Reviewer Reply: "newly differentiated cells" is what was written, but "newly differentiating" and "newly differentiated" are hard to really to distinguish regardless.
But there is much to be said for distinguishing, regardless of which theory of the right to secede is adopted, between the right to secede (understood as the right to repudiate the state's authority over a portion of its territory and to attempt to set up a new state there) and the right to recognition as a legitimate state.
However, clustering methods may distinguish groups regardless of whether they exist in the population as true entities or not.
For example, two of the sixteen endpoint lineages presented exactly the same genetic sequence, rendering it impossible to distinguish them, regardless of the method employed.
Although we have noted the presence of a common gene signature that is able to distinguish HCCs regardless of etiological factors, suggesting a convergence of signaling cascades in HCC formation, we also observed that AFB1 exposure or the presence of HBsAg has some molecularly distinguishing features (supplementary material Fig. S3).
Pattern recognition receptors also distinguished the macrophage populations regardless of breed background.
In 1928 Alexander discovered an invariant polynomial, now known as the Alexander polynomial, for distinguishing various knots regardless of how they are stretched or twisted.
Generally, these continuing changes cannot be distinguished from normal aging processes that occur regardless of whether a person has been treated orthodontically or not.
We investigated the effect on the complete stand including all trees (⩾10 cm DBH) regardless of species, but also distinguished between the effects on the commercially interesting species of dipterocarps (Dipterocarpaceae family) and pioneer species (mainly Macaranga species).
