A pattern of gene expression could be identified that effectively distinguished mice irradiated to AH compared to non-irradiated mice (Figure 1A).
Cluster analysis demonstrated that the first coordinate (28%) distinguished mice based on the genetics of the host, whilst the second coordinate (16%) differentiated based on the diet (Fig 5A).
However, some of the Hprt primers were designed to distinguish mouse and rat in order to exclude cross-contaminations between rat and mouse samples.
Such factors, distinguishing mouse and human AVPR1A structure and function, present a challenge to the in vivo evaluation of therapeutic compounds targeted to humans, in rodent models.
Importantly, elevated total serum immunoglobulin concentrations, including elevation in autoantibodies, distinguish mouse strains with increased numbers of MZ, B1, and memory B cell subsets, and not surprisingly aged mice [ 12, 39- 41].
If this were the case, the genes that most distinguish mouse soleus from other mouse muscles, and most represent its similarities to human muscles, should include a significant number of fiber type specific genes.
Following Hoaglin and others [ 59], univariate analyses (ANOVA) were applied in an exploratory sense to determine the magnitude and direction of site differences for those variables found (using Discriminant Function Analysis) to distinguish mouse lemurs at the three sites.
To clearly distinguish mouse genome Abp paralogues predicted here from those previously reported [ 8] and from those derived from other species/subspecies, we designate our current paralogues with the prefix B6, in reference to the C57BL/6J strain whose genome has been sequenced.
This study evaluated the ability of a Radial Water Tread (RWT) maze, designed specifically for mice, that requires no swimming to distinguish mice with controlled cortical impact (CCI) induced TBI and Sham controls.
This study revealed that sex differences can impact the accuracy of this approach, particularly in distinguishing mice exposed to lower dose irradiation from non-irradiated controls.
