As we use the term and define it mathematically, a utility threshold distinguishes modifications in pressure that have a large effect on an attribute's value from changes that have a much smaller influence [9].
Weygand distinguished seven modifications (called "main forms") as monotropically related with a high probability.
Integration of the expression status and of the differential DNA methylation status with histone modification profiles has allowed us to distinguish histone modifications associated with imprinting from those more often associated with developmental repression.
This analytical framework consists of a series of actualistic experiments designed to determine those variables useful for distinguishing between modifications produced via pre-mortem and post-depositional processes that can damage molluscan shell, and damage produced via use as an expedient tool.
We have reached a similar conclusion, but were able to separate the centromeric and telomeric regions and distinguish the modifications that are enriched in each of these regions.
A major limitation with current mass spectrometry based methods however is the inability to distinguish among modifications by ubiquitination, NEDD8 or ISG15, due to an identical di-Gly remnant generated by trypsin proteolysis of the modified proteins [ 112].
Briefly, by using a QqQ mass spectrometer with selective reaction monitoring (SRM), we are able to distinguish different modifications on the histone fragments and can use this to quantitate the amount of acetylation of a given lysine.
Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications.
The determination of architectural indices allowed us to distinguish a modification of biodiversity along a disturbance gradient for population level.
Similarly, the nominal p value threshold of<0.05 was also used to distinguish the modification changed genes.
Moreover, the use of a mutated DAPK catalytic domain relaxed the dimerization capability, allowing us to distinguish a modification of the probe binding affinity due to experimental conditions (seen both with the wild type and the mutated core domain of the kinase) or due to dimerization (only seen with the wild type core domain).
