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They can be distinguished from the type of neuroglia known as an astrocyte by the greater density of both the cytoplasm and the nucleus, the absence of fibrils and of glycogen in the cytoplasm, and large numbers of microtubules in the processes.
Although these profiles truly represent concurrent PrPSc fragments, and the 20 and 18.5 kDa fragments likely reflect specific PK cleavage sites, the 20 and 18.5 kDa bands are distinguished from the type 1 and type 2 fragments because, at least to date, they were never detected independently from types 1 and 2, and are not markers of specific clinico-pathological phenotypes.
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The first published record of Type A in this area was in 2007 [ 26], but as Type A and B were only recognized in 2005 [ 48], Type A living in this area prior to 2005 would not have been distinguished from the native Type B. However, the introduction of Type A was likely human-mediated [ 26], and therefore a recent invasion on an evolutionary timescale.
As the rice grows, significant phenotypic differences could be distinguished from the two type plants.
Recombinant virus was distinguished from the wild type virus by using the plaque assay method [ 28].
On a molecular level, DGC is distinguished from the intestinal type on the basis of its abnormal expression of the cell-cell adhesion molecule E-cadherin [ 4].
ΔGR expression was studied using western blotting since this protein cannot be distinguished from the wild-type GR using immunohistochemistry.
The hydrolysis assay results were compared with the DNA sequence results and all nine samples containing an exon 19 deletion were correctly identified and distinguished from the wild-type specimen (Figure 2b).
Somatostatin-containing interneurons also displayed small nuclei with heterochromatin located in a single central clump, but could be distinguished from the other types of interneurons by their elongated nuclei (axis ratio ≥1.5), in agreement with previous studies in which the fusiform perikarya of somatostatin-positive neurons was defined as a typical morphological characteristic [29] (Fig. 3D).
These embryos were distinguished from the wild-type and heterozygous littermates by an eyeless phenotype.
Under normal environmental conditions, the phenotype of the AtCHR12 mutant cannot be distinguished from the wild-type.
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