However, from this study we can't distinguish alterations in gene expression between strains that are due to differences in neuropathology and those due to mice being at slightly differently stages of infection.
Domesticated populations were matched to wild-type fish of either the same age or the same size (year older) in order to distinguish alterations in mRNA expression that have arisen due to differences in fish developmental stage rather than due to domestication.
We have distinguished the expected alterations, the alterations that are present in man and absent in the animal, and finally the lesions that raise new questions or suggest new points of view.
However, it is important to distinguish between alterations in levels of activity in individual brain regions from changes in connectivity between regions.
A recent SNP-based survey [1] of 3,131 copy-number profiles derived from over 26 different types of cancer has provided a dramatic illustration of the power of high-throughput techniques in distinguishing random alterations in the genome from those that may have a direct impact on tumorigenesis.
Cell cycle analysis via flow cytometry allowed us to distinguish between alterations in proliferation and apoptosis.
Therefore, different trimester-specific reference ranges were defined to distinguish physiological alterations from pathological states [ 13– 15].
Preliminary results on TBI patients show promise, since the method is able to distinguish between alterations that affect tissue versus those that affect the extracellular space [ 43].
However, to distinguish genetic alterations which confer strong advantages to the tumor cell (drivers) from the more numerous neutral aberrations (passengers) is a difficult task.
Distinguishing the alterations that give cancer cells a selective advantage (drivers) from those that are merely side effects (passengers) of the destabilization of the cancer genome is a major problem in oncogenomics research.
Therefore, we made an effort to distinguish the alterations of gray and white matter structures that we hypothesize to be underlying RDP, from vascular and neurodegenerative pathology, associated with aging and Alzheimer disease.
