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Next, structure-activity analyses distinguished active regions in the compound and led to the identification of highly potent analogs that killed cancer cells with an efficacy equaling that of established spindle drugs.
Use of this score would have correctly distinguished active therapy from placebo in earlier trials and thus would have avoided some of their misleading conclusions.
And so, two types of variables were distinguished: active variables which contribute to create factorial axes, and illustrative variables which permit to improve the analysis by calculating the Pearson's chi-square (χ2).
Eight out of 29 biomarkers distinguished active TB from LTBI in a pilot study.
Nevertheless, four possible roles were distinguished: active or passive psychological support; witness of the event, and/or instrument.
Further, Creyghton et al. [6] proposed that acetylation of histone H3 at lysine 27 (H3K27ac) distinguished active enhancers from inactive/poised enhancer elements containing H3K4me1 alone.
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In this study, traditional continuous and binary QSAR models were built to classify the biological activities of previously identified compounds and to distinguish active compounds from inactive compounds for drug development based on the calculated molecular and physicochemical properties.
The activity threshold defines a certain velocity limit to distinguish active from inactive behavior (1 cm/s).
(This is what distinguishes "active matrix" LCDs from blurry "passive matrix" ones).
Regardless of the applied methods, one typically attempts to distinguish "active" from "inactive" compounds.
The task of the ML algorithm was to distinguish active from inactive or decoy compounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com