Distinguishable functions describe the hexagonal FCC (1 1 1) and HCP (0 0 0 1) surfaces, but a single function describes the FCC (1 0 0) and BCC (1 0 0) surfaces.
Interestingly, OPA1 has genetically distinguishable functions in mitochondrial fusion and release of cytochrome c during apoptosis [18].
OPA1, mutated in dominant optic atrophy [2,12], is a multifaceted mitochondria-shaping protein that has genetically distinguishable functions in apoptosis [9,18,28,34] and in mitochondrial fusion [8].
The distinguishable functions of survivin in individual subcellular compartments are most likely realized through the domain structure of the molecule and regulated by secondary modifications.
Understanding the links between these two distinguishable functions is, of course, complicated in humans by the myriad ways we learn to associate them, so our monkey behavior can provide a simplified model.
Our results support the hypothesis that these components function together in an integrated ciliary delivery pathway and suggest that they have distinguishable functional effects in the delivery pathway.
In the 1960s and '70s, the nuclear submarine was the single most important instrument of sea power; it was scarcely distinguishable in function from strategic air power and land-based missiles in general nuclear warfare.
A comparative analysis of miRNA expression profiles of two stromal cell lines, distinguishable by function and by CXCL12 expression (CXCL12+ and CXCL12−), revealed that the CXCL12− cells expressed >40 fold more miR-886-3p miR-886-3p miR-886-3ps.
The two classes of repressed genes are further distinguishable by function and sensitivity to DNase digestion, with gene promoters losing H3K4me3 located within relatively condensed chromatin compared to promoters that retain H3K4me3.
Thus, despite their use of the same receptor, IFNβ and IFNα have unique and distinguishable biologic functions, with IFNβ being mainly responsible for promoting viral persistence.
