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Although, on the molecular level, different genetic defects must result in specific and distinguishable defects (defective assembly or increased degradation, increased reactive oxygen species production or impaired catalysis or regulation), the in vivo consequences of individual mutations vary significantly between tissues and produce different clinical profiles in different patients.
In contrast, the ΔetrA strain did not show distinguishable defects in growth with any of the tested EAs compared to the parental strain MR-1 (Table 2).
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Surprisingly, however, no distinguishable defect in the microtubule network was found in cells microinjected with EspG, despite fragmented Golgi.
(A ) DIC images of distinguishable phenotypic defects in GCs in FAMALGK plants (FAMAp:FAMA LGK ; fama ).
The defects were clearly distinguishable on MRI three and six months postoperative with a persistent large defect in the empty defects and smooth and slightly depressed surface of non-hyaline tissue in the MACI group (Fig. 4).
The different electron-transfer (ET) kinetics, including the bimolecular ET between the porphyrin self-assembled monolayers (SAMs) and the redox mediator [K3Fe CN 6], the tunneling ET between the underlying gold electrode and [K3Fe CN 6], and pinholes or defects, were clearly distinguishable.
Genotype of rSey2/+ rats was externally distinguishable because they have eye defects [27].
No healing was seen in the control group and, the margins of the defects were clearly distinguishable with minimal filling of the reparative tissue.
Following marrow stimulation, the region of the articular cartilage defect was clearly distinguishable.
Initial experiments in November 2010 showed clear defects that represented several distinguishable phenotypes in the treated embryos.
Clinically distinguishable spondylometaphyseal dysplasia, Kozlowski type (SMDK) presents defects intermediate in severity [9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com