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Although not done in this study, comprehensive MS analysis of many patients may help to distinguish variations between patients, and with disease stratification and the identification of judicious therapeutic targets.
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Ideally, we would also include the nursing home frailty λ i to distinguish variation between nursing homes from variation between residents within homes.
This genome duplication complicates the discovery of genuine bi-allelic SNPs as it can be difficult in bioinformatics analyses to distinguish variation between paralogous loci from genuine SNP variation at unique genome locations (e.g.[ 12, 29- 31]).
GPFARM simulations matched observed data trends, with the model correctly distinguishing variations between the summit and toeslope landscape positions.
Despite the essential role of spawning migration in the life-cycle of Atlantic salmon, very few studies have investigated population-specific differences in run timing apart from distinguishing variation between sea-age groups.
While there was considerable overlap in the phosphoproteins identified from LC-MS/MS analysis between different patients (CLL A – E), more comprehensive MS analysis of multiple patients may help to distinguish variations in signaling responses between patients.
Combining MTV with qT1 mapping may potentially provide new information about variations in local physico-chemical environments, while combining it with DTI imaging may help to distinguish between variations in tissue orientation and tissue density.
It is a common clinical observation, however, that is not always easy to distinguish between variations of BP and BTcP.
The VAF for the not confirmed SNV (13%) is in the range for 1 deviating copy out of 6 (16.67%) indicating the difficulty to distinguish between variations of this type and false positives of the applied method.
The authors postulated that this arises from the actual unit cell being larger than the average unit cell of the P4/ mbm space group used in the refinement of the diffraction data (a larger cell having been observed in their electron diffraction studies), NMR being sensitive enough to distinguish between variations of different ordering schemes for at least one of the two environments.
The ranking process has been criticised for failing to take sufficient account of case-mix and failing to distinguish between variation due to chance and variation due to special causes [ 6].
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